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Aberrant Methylation of <i>RASGRF1</i> Is Associated with an Epigenetic Field Defect and Increased Risk of Gastric Cancer

8 Sept 2012

Abstract excerpt

Aberrant DNA methylation is implicated in the epigenetic field defect seen in gastric cancer. Our aim in this study was to identify predictive biomarkers by screening for DNA methylation in noncancerous background gastric mucosa from patients with gastric cancer. Using methylated-CpG island amplification coupled with CpG island microarray (MCAM) analysis, we identified 224 genes that were methylated in the...

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PMID: 22961779
DOI: 10.1158/1940-6207.capr-12-0056

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