Polymorphic rs9471643 and rs6458238 upregulate PGC transcription and protein expression in overdominant or dominant models.

doi:10.1002/mc.22305

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Polymorphic rs9471643 and rs6458238 upregulate PGC transcription and protein expression in overdominant or dominant models.

Molecular carcinogenesis - 1 May 2016

He Caiyun, Xu Qian, Tu Huakang, Sun Liping, Gong Yuehua, Liu Jingwei, Yuan Yuan

Abstract excerpt

The pepsinogen C (PGC) gene encodes a major differentiation biomarker for gastric mucosa and has two single nucleotide polymorphisms, rs9471643 G>C and rs6458238 G>A, within its 5' upstream region that are involved in gastric carcinogenesis. However, in what genetic models the two polymorphisms modulate disease risk and how they relate to gastric carcinogenesis needs further study. We fitted the most appropriate...

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PMID: 25857852
DOI: 10.1002/mc.22305

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