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Article

Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis.

BMC medical genetics - 12 Oct 2020

Sakurai Naoko, Shibata Tomoyuki, Nakamura Masakatsu, Takano Hikaru, Hayashi Tasuku, Ota Masafumi, Nomura-Horita Tomoe, Hayashi Ranji, Shimasaki Takeo, Ostuka Toshimi, Tahara Tomomitsu, Arisawa Tomiyasu

Abstract excerpt

BACKGROUND: CDKN2A hypermethylation is among the major events associated with carcinogenesis and is also observed in non-neoplastic colonic mucosa in patients with ulcerative colitis (UC). Macrophage migration inhibitory factor (MIF) plays a crucial role in promoting gastrointestinal inflammation characteristic of UC. The aim of this study is to explore associations between CDKN2A methylation status and MIF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33046033
DOI: 10.1186/s12881-020-01140-9
PMCID: PMC7552536

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