Article
Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating.
Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2021
Zhao Lijuan, Xie Haibo, Kang Yunsi, Lin Yiwen, Liu Gai, Sakato-Antoku Miho, Patel-King Ramila S, Wang Bing, Wan Cuihong, King Stephen M, Zhao Chengtian, Huang Kaiyao
Abstract excerpt
Coordinated beating is crucial for the function of multiple cilia. However, the molecular mechanism is poorly understood. Here, we characterize a conserved ciliary protein CYB5D1 with a heme-binding domain and a cordon-bleu ubiquitin-like domain. Mutation or knockdown of Cyb5d1 in zebrafish impaired coordinated ciliary beating in the otic vesicle and olfactory epithelium. Similarly, the two flagella of an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.