Article
A Forward Genetic Screen and Whole Genome Sequencing Identify Deflagellation Defective Mutants in Chlamydomonas, Including Assignment of ADF1 as a TRP Channel.
G3 (Bethesda, Md.) - 13 Oct 2016
Hilton Laura K, Meili Fabian, Buckoll Paul D, Rodriguez-Pike Julie C, Choutka Courtney P, Kirschner Jaime A, Warner Freda, Lethan Mette, Garces Fabian A, Qi Jingnan, Quarmby Lynne M
Abstract excerpt
With rare exception, ciliated cells entering mitosis lose their cilia, thereby freeing basal bodies to serve as centrosomes in the formation of high-fidelity mitotic spindles. Cilia can be lost by shedding or disassembly, but either way, it appears that the final release may be via a coordinated severing of the nine axonemal outer doublet microtubules linking the basal body to the ciliary transition zone. Little...
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