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Article

Repeated treatment with VEGF receptor inhibitors induces phenotypic changes in endothelial cells and pericytes in the rat retina.

Microvascular research - 1 Jan 2025

Nakano Ayuki, Kawada Takaaki, Morita Akane, Nakahara Tsutomu

Abstract excerpt

Abnormal ocular angiogenesis is a major cause of visual impairment and vision loss in neovascularization-related diseases. Currently, anti-vascular endothelial growth factor (VEGF) drugs are used to treat ocular neovascularization, but repeated injections are needed to maintain their therapeutic effects. However, repeated injection of anti-VEGF drugs may affect the retinal blood vessel phenotype and diminish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39454823
DOI: 10.1016/j.mvr.2024.104756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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