Article
High-throughput interrogation of PIK3CA, PTEN, KRAS, FBXW7 and TP53 mutations in primary endometrial carcinoma.
Gynecologic oncology - 1 Feb 2013
Garcia-Dios Diego A, Lambrechts Diether, Coenegrachts Lieve, Vandenput Ingrid, Capoen An, Webb Penelope M, Ferguson Kaltin, Akslen Lars A, Claes Bart, Vergote Ignace, Moerman Philippe, Van Robays Johan, Marcickiewicz Janusz, Salvesen Helga B, Spurdle Amanda B, Amant Frédéric
Abstract excerpt
OBJECTIVE: Endometrial cancer patients may benefit from systemic adjuvant chemotherapy, alone or in combination with targeted therapies. Prognostic and predictive markers are needed, however, to identify patients amenable for these therapies. METHODS: Primary endometrial tumors were genotyped for >100 hot spot mutations in genes potentially acting as prognostic or predictive markers. Mutations were correlated...
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