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Article

Molecular basis for higher affinity of SARS-CoV-2 spike RBD for human ACE2 receptor.

Proteins - 1 Sept 2021

Delgado Julián M, Duro Nalvi, Rogers David M, Tkatchenko Alexandre, Pandit Sagar A, Varma Sameer

Abstract excerpt

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused substantially more infections, deaths, and economic disruptions than the 2002-2003 SARS-CoV. The key to understanding SARS-CoV-2's higher infectivity lies partly in its host receptor recognition mechanism. Experiments show that the human angiotensin converting enzyme 2 (ACE2) protein, which serves as the primary receptor for both CoVs, binds...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33864655
DOI: 10.1002/prot.26086
PMCID: PMC8250905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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