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Computational prediction of the effect of mutations in the receptor-binding domain on the interaction between SARS-CoV-2 and human ACE2.

Molecular diversity - 1 Dec 2022

Celik Ismail, Khan Abbas, Dwivany Fenny Martha, Fatimawali, Wei Dong-Qing, Tallei Trina Ekawati

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 continues to mutate. Numerous studies have indicated that this viral mutation, particularly in the receptor-binding domain area, may increase the viral affinity for human angiotensin-converting enzyme 2 (hACE2), the receptor for viral entry into host cells, thereby increasing viral virulence and transmission. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35138508
DOI: 10.1007/s11030-022-10392-x

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