Article

Mechanistic origin of different binding affinities of SARS-CoV and SARS-CoV-2 spike RBDs to human ACE2

2022-02-07

Abstract excerpt

The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein mediates viral entry into host cells through binding to the cell-surface receptor angiotensin-converting enzyme 2 (ACE2). It has been shown that SARS-CoV-2 RBD (RBD CoV2 ) has a higher binding affinity to human ACE2 than its highly homologous SARS-CoV RBD (RBD CoV ), for which the mechanistic reasons still remain to be elucidated. Here, we used th...

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Literature Corpus work: b217590f-da81-5166-bd0b-81ec877df992
DOI: 10.1101/2022.02.05.479221

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