Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.

doi:10.1016/j.jbc.2021.101151

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Article

Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.

The Journal of biological chemistry - 1 Oct 2021

Prévost Jérémie, Richard Jonathan, Gasser Romain, Ding Shilei, Fage Clément, Anand Sai Priya, Adam Damien, Gupta Vergara Natasha, Tauzin Alexandra, Benlarbi Mehdi, Gong Shang Yu, Goyette Guillaume, Privé Anik, Moreira Sandrine, Charest Hugues, Roger Michel, Mothes Walther, Pazgier Marzena, Brochiero Emmanuelle, Boivin Guy, Abrams Cameron F, Schön Arne, Finzi Andrés

Abstract excerpt

The seasonal nature of outbreaks of respiratory viral infections with increased transmission during low temperatures has been well established. Accordingly, temperature has been suggested to play a role on the viability and transmissibility of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. The receptor-binding domain (RBD) of the Spike glycoprotein is known to bind to its host receptor...

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Identifiers

PMID: 34478710
DOI: 10.1016/j.jbc.2021.101151
PMCID: PMC8406544

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