Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of phenotypic heterogeneity and microenvironment feedback in early tumor development.

Physical review. E - 1 Mar 2021

Smart Matthew, Goyal Sidhartha, Zilman Anton

Abstract excerpt

The local microenvironment of a tumor plays an important and commonly observed role in cancer development and progression. Dynamic changes in the tissue microenvironment are thought to epigenetically disrupt healthy cellular phenotypes and drive cancer incidence. Despite the experimental work in this area there are no conceptual models to understand the interplay between the epigenetic dysregulation in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenesis, Genetic
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Models, Biological

Share to Neoplasms

Share to Phenotype

Share to Tumor Microenvironment

Source

Identifiers

PMID: 33862830
DOI: 10.1103/PhysRevE.103.032407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of phenotypic heterogeneity and microenvironment feedback in early tumor development.PMID 33862830Read ↗

Reimagining Cancer: Moving from the Cellular to the Tissue LevelSemantic proximity Read ↗

Why is cancer not more common? A changing microenvironment may help to explain why, and suggests strategies for anti-cancer therapy.Semantic proximity Read ↗

Selective evolutionary pressure from the tissue microenvironment drives tumor progressionSemantic proximity Read ↗

Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer.Semantic proximity Read ↗

The tumor microenvironment: a critical determinant of neoplastic evolutionSemantic proximity Read ↗

An evolutionary model for initiation, promotion, and progression in carcinogenesisSemantic proximity Read ↗

Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity.Semantic proximity Read ↗

Fluctuating environment causes neoplastic transition and epithelial-mesenchymal plasticity in human cellsSemantic proximity Read ↗

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel.Semantic proximity Read ↗

Interplay of Driver, Mini-Driver, and Deleterious Passenger Mutations on Cancer ProgressionSemantic proximity Read ↗

Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells.Semantic proximity Read ↗

The influence of the microenvironment on the malignant phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.