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Article

The influence of the microenvironment on the malignant phenotype.

Molecular medicine today - 1 Aug 2000

Park C C, Bissell M J, Barcellos-Hoff M H

Abstract excerpt

Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. As tissue becomes cancerous, there are reciprocal interactions between neoplastic cells, adjacent normal cells such as stroma and endothelium, and their microenvironments. The current dominant paradigm wherein multiple genetic lesions provide both the impetus for, and the Achilles heel of, cancer...

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PMID: 10904250
DOI: 10.1016/s1357-4310(00)01756-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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