Article
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy.
Nature - 17 Oct 2013
Mangravite Lara M, Engelhardt Barbara E, Medina Marisa W, Smith Joshua D, Brown Christopher D, Chasman Daniel I, Mecham Brigham H, Howie Bryan, Shim Heejung, Naidoo Devesh, Feng QiPing, Rieder Mark J, Chen Yii-Der I, Rotter Jerome I, Ridker Paul M, Hopewell Jemma C, Parish Sarah, Armitage Jane, Collins Rory, Wilke Russell A, Nickerson Deborah A, Stephens Matthew, Krauss Ronald M
Abstract excerpt
Statins are prescribed widely to lower plasma low-density lipoprotein (LDL) concentrations and cardiovascular disease risk and have been shown to have beneficial effects in a broad range of patients. However, statins are associated with an increased risk, albeit small, of clinical myopathy and type 2 diabetes. Despite evidence for substantial genetic influence on LDL concentrations, pharmacogenomic trials have...
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