Article
Functional Analysis of DNMT1 SNPs (rs2228611 and rs2114724) Associated with Schizophrenia.
Genetics research - 1 Jan 2021
Saxena Sonal, Maroju Pranay Amruth, Choudhury Sumana, Voina Vidhya Chitta, Naik Poonam, Gowdhaman Kavitha, Kkani Poornima, Chennoju Kiranmai, Ganesh Kumar S, Ramasubramanian C, Prasad Rao G, Jamma Trinath, Narayan Kumar Pranav, Mohan K Naga
Abstract excerpt
A recent study showed the association of minor alleles of rs2228611 (T allele) and rs2114724 (T allele) of DNMT1 with schizophrenia (SZ) and suggested their effects on splicing of the transcripts. We performed a replication study using 310 controls and 304 SZ patients and confirmed the association of the homozygous minor allele genotypes with SZ (P = 0.04 for rs2114724 and P = 0.007 for rs2228611). This...
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