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Article

Haplotype-based association between paternal DNMT1 variants and nonsyndromic cleft lip or without cleft palate in Chile.

Journal of the World federation of orthodontists - 1 Jun 2025

Inostroza Verónica, Pantoja Roberto, Leiva Noemí, Pardo Rosa, Suazo José

Abstract excerpt

BACKGROUND: DNA methyltransferase 1 (DNMT1) is responsible for epigenetic remodeling of the genome during spermatogenesis and maintenance of DNA methylation. The current study aimed to assess the possible association between paternal polymorphic variants of the gene encoding DNMT1 enzyme and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression in offspring. METHODS: Nine DNMT1...

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Chile
Cleft Lip
Cleft Palate
DNA (Cytosine-5-)-Methyltransferase 1
DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Methylation

Paternal Inheritance

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Identifiers

PMID: 40069042
DOI: 10.1016/j.ejwf.2025.01.004

Genes

DNMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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