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Article

High circulating insulin-like growth factor-1 reduces the risk of renal cell carcinoma: a Mendelian randomization study.

Carcinogenesis - 21 Jun 2021

Chen Meng, Tsai Chia-Wen, Chang Wen-Shin, Xiong Grace Y, Xu Yifan, Bau Da-Tian, Gu Jian

Abstract excerpt

Insulin and insulin-like growth factors play important roles in carcinogenesis. Circulating insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) have been linked to cancer susceptibility. The associations of circulating IGF-1 and IGFBP-3 with the risk of renal cell carcinoma (RCC) are inconsistent. Recent large genome-wide association studies have identified 413 single...

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Identifiers

PMID: 33852723
DOI: 10.1093/carcin/bgab031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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