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Article

HLA Zygosity Increases Risk of Hepatitis B Virus-Associated Hepatocellular Carcinoma.

The Journal of infectious diseases - 22 Nov 2021

Liu Zhiwei, Huang Chih-Jen, Huang Yu-Han, Pan Mei-Hung, Lee Mei-Hsuan, Yu Kelly J, Pfeiffer Ruth M, Viard Mathias, Yuki Yuko, Gao Xiaojiang, Carrington Mary, Chen Chien-Jen, Hildesheim Allan, Yang Hwai-I

Abstract excerpt

BACKGROUND: Diversity in the HLA genes might be associated with disease outcomes-the heterozygote advantage hypothesis. We tested this hypothesis in relation to hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). METHODS: We utilized DNA from > 10 000 Taiwanese individuals with current or past HBV infection to examine the association between HLA diversity and critical natural history steps in the...

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Identifiers

PMID: 33852009
DOI: 10.1093/infdis/jiab207
PMCID: PMC9633721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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