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Article

SnoN as a novel negative regulator of TGF-β/Smad signaling: a target for tailoring organ fibrosis

7 Nov 2014

Abstract excerpt

Remodeling of the extracellular matrix is beneficial during the acute wound healing stage following tissue injury. In the short term, resident fibroblasts and myofibroblasts regulate the matrix remodeling process through production of matricellular protein components that provide structural support to the damaged tissue. This process is largely governed by the transforming growth factor-β1 (TGF-β1) pathway, a...

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PMID: 25380815
DOI: 10.1152/ajpheart.00453.2014

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