Article
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices.
Nature communications - 12 Apr 2021
Natarajan Pradeep, Pampana Akhil, Graham Sarah E, Ruotsalainen Sanni E, Perry James A, de Vries Paul S, Broome Jai G, Pirruccello James P, Honigberg Michael C, Aragam Krishna, Wolford Brooke, Brody Jennifer A, Antonacci-Fulton Lucinda, Arden Moscati, Aslibekyan Stella, Assimes Themistocles L, Ballantyne Christie M, Bielak Lawrence F, Bis Joshua C, Cade Brian E, Do Ron, Doddapaneni Harsha, Emery Leslie S, Hung Yi-Jen, Irvin Marguerite R, Khan Alyna T, Lange Leslie, Lee Jiwon, Lemaitre Rozenn N, Martin Lisa W, Metcalf Ginger, Montasser May E, Moon Jee-Young, Muzny Donna, O'Connell Jeffrey R, Palmer Nicholette D, Peralta Juan M, Peyser Patricia A, Stilp Adrienne M, Tsai Michael, Wang Fei Fei, Weeks Daniel E, Yanek Lisa R, Wilson James G, Abecasis Goncalo, Arnett Donna K, Becker Lewis C, Blangero John, Boerwinkle Eric, Bowden Donald W, Chang Yi-Cheng, Chen Yii-Der I, Choi Won Jung, Correa Adolfo, Curran Joanne E, Daly Mark J, Dutcher Susan K, Ellinor Patrick T, Fornage Myriam, Freedman Barry I, Gabriel Stacey, Germer Soren, Gibbs Richard A, He Jiang, Hveem Kristian, Jarvik Gail P, Kaplan Robert C, Kardia Sharon L R, Kenny Eimear, Kim Ryan W, Kooperberg Charles, Laurie Cathy C, Lee Seonwook, Lloyd-Jones Don M, Loos Ruth J F, Lubitz Steven A, Mathias Rasika A, Martinez Karine A Viaud, McGarvey Stephen T, Mitchell Braxton D, Nickerson Deborah A, North Kari E, Palotie Aarno, Park Cheol Joo, Psaty Bruce M, Rao D C, Redline Susan, Reiner Alexander P, Seo Daekwan, Seo Jeong-Sun, Smith Albert V, Tracy Russell P, Vasan Ramachandran S, Kathiresan Sekar, Cupples L Adrienne, Rotter Jerome I, Morrison Alanna C, Rich Stephen S, Ripatti Samuli, Willer Cristen, Peloso Gina M
Abstract excerpt
Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on...
