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Legend or Truth: Mature CD4+CD8+ Double-Positive T Cells in the Periphery in Health and Disease

5 Oct 2023

Abstract excerpt

The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with specialized functions. While CD4+ T cells support and modulate immune responses through different T-helper (Th) and regulatory subtypes, CD8+ T cells eliminate cells that might threaten the organism, for example, virus-infected or tumor cells. However, a paradoxical population of CD4+CD8+ double-positive (DP) T cells...

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PMID: 37893076
DOI: 10.3390/biomedicines11102702

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