Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatiotemporal Manipulation of the Mismatch Repair System of Pseudomonas putida Accelerates Phenotype Emergence.

ACS synthetic biology - 21 May 2021

Fernández-Cabezón Lorena, Cros Antonin, Nikel Pablo I

Abstract excerpt

The development of complex phenotypes in industrially relevant bacteria is a major goal of metabolic engineering, which encompasses the implementation of both rational and random approaches. In the latter case, several tools have been developed toward increasing mutation frequencies, yet the precise control of mutagenesis processes in cell factories continues to represent a significant technical challenge....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mismatch Repair
Share to Genes, Bacterial
Share to Metabolic Engineering

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Metabolic Networks and Pathways

Share to Mutagenesis

Share to Mutation Rate

Share to MutL Proteins

Share to Pseudomonas putida

Source

Identifiers

PMID: 33843192
DOI: 10.1021/acssynbio.1c00031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal Manipulation of the Mismatch Repair System of Pseudomonas putida Accelerates Phenotype Emergence.PMID 33843192Read ↗

A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species.Semantic proximity Read ↗

Engineering multiple genomic deletions in Gram-negative bacteria: analysis of the multi-resistant antibiotic profile of Pseudomonas putida KT2440.Semantic proximity Read ↗

Impact of transient acquired hypermutability on the inter- and intra-species competitiveness of Pseudomonas aeruginosa.Semantic proximity Read ↗

Targeted genetic screening in bacteria with a Cas12k-guided transposase.Semantic proximity Read ↗

Transient overexpression of DNA adenine methylase enables efficient and mobile genome engineering with reduced off-target effects.Semantic proximity Read ↗

General and inducible hypermutation facilitate parallel adaptation in Pseudomonas aeruginosa despite divergent mutation spectra.Semantic proximity Read ↗

A self-propagating, barcoded transposon system for the dynamic rewiring of genomic networks.Semantic proximity Read ↗

A novel papillation assay for the identification of genes affecting mutation rate in Pseudomonas putida and other pseudomonads.Semantic proximity Read ↗

A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria.Semantic proximity Read ↗

An in vivo target mutagenesis system for multiple hosts.Semantic proximity Read ↗

CRISPR/Cas9-Based Counterselection Boosts Recombineering Efficiency in Pseudomonas putida.Semantic proximity Read ↗

Escherichia coli with a Tunable Point Mutation Rate for Evolution Experiments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.