Article
Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jun 2021
Franco Nicola Rares, Massi Michela Carlotta, Ieva Francesca, Manzoni Andrea, Paganoni Anna Maria, Zunino Paolo, Veldeman Liv, Ost Piet, Fonteyne Valérie, Talbot Christopher J, Rattay Tim, Webb Adam, Johnson Kerstie, Lambrecht Maarten, Haustermans Karin, De Meerleer Gert, de Ruysscher Dirk, Vanneste Ben, Van Limbergen Evert, Choudhury Ananya, Elliott Rebecca M, Sperk Elena, Veldwijk Marlon R, Herskind Carsten, Avuzzi Barbara, Noris Chiorda Barbara, Valdagni Riccardo, Azria David, Farcy-Jacquet Marie-Pierre, Brengues Muriel, Rosenstein Barry S, Stock Richard G, Vega Ana, Aguado-Barrera Miguel E, Sosa-Fajardo Paloma, Dunning Alison M, Fachal Laura, Kerns Sarah L, Payne Debbie, Chang-Claude Jenny, Seibold Petra, West Catharine M L, Rancati Tiziana
Abstract excerpt
AIM: To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS: Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal...
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