Article

Human Blood-Derived Lymphoblastoid Cybrids for Assessment of Mitochondrial tRNAs Deficiency by MTO1 Silence

2021-12-21

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Mutations in the mitochondrial translation optimization 1 (MTO1) gene can cause hypertrophic cardiomyopathy. Although the functional role of MTO1 deficiency in certain cells is gradually confirmed, the phenotype of MTO1 deficiency in a lymphoblastoid cybrid line is not yet reported. In this study, we characterized changes of mitochondrial function in MTO1 silenc...

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Literature Corpus work: 008eca9d-5dd1-5b8a-9dfa-73a2cc5f20ca
DOI: 10.21203/rs.3.rs-208835/v2

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