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Article

Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells.

Free radical biology & medicine - 15 Dec 2008

Schwarzer Christian, Fischer Horst, Kim Eun-Jin, Barber Katharine J, Mills Aaron D, Kurth Mark J, Gruenert Dieter C, Suh Jung H, Machen Terry E, Illek Beate

Abstract excerpt

Pyocyanin (N-methyl-1-hydroxyphenazine), a redox-active virulence factor produced by the human pathogen Pseudomonas aeruginosa, is known to compromise mucociliary clearance. Exposure of human bronchial epithelial cells to pyocyanin increased the rate of cellular release of H(2)O(2) threefold above the endogenous H(2)O(2) production. Real-time measurements of the redox potential of the cytosolic compartment using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cystic Fibrosis Transmembrane Conductance Regulator

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Source

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Identifiers

PMID: 18845244
DOI: 10.1016/j.freeradbiomed.2008.09.011
PMCID: PMC2628806

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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