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Article

Mislocalization of CFTR expression in acute pancreatitis and the beneficial effect of VX-661 + VX-770 treatment on disease severity.

The Journal of physiology - 1 Nov 2021

Fűr Gabriella, Bálint Emese Réka, Orján Erik Márk, Balla Zsolt, Kormányos Eszter Sára, Czira Beáta, Szűcs Attila, Kovács Dénes Péter, Pallagi Petra, Maléth József, Venglovecz Viktória, Hegyi Péter, Kiss Lóránd, Rakonczay Zoltán

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) has an essential role in maintaining pancreatic ductal function. Impaired CFTR function can trigger acute pancreatitis (AP) and exacerbate disease severity. We aimed to investigate the localization and expression of CFTR during AP, and determined the effects of a CFTR corrector (VX-661) and potentiator (VX-770) on disease severity. AP was induced in FVB/n...

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PMID: 34587656
DOI: 10.1113/JP281765

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