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Telomere associated gene expression as well as TERT protein level and telomerase activity are altered in the ovarian follicles of aged mice

30 Jul 2021

Abstract excerpt

Telomeres cap the ends of eukaryotic chromosomes to maintain genomic stability and integrity during an organism's lifespan. The length of telomeres inevitably shortens due to DNA replication, genotoxic agents, and biological aging. A limited number of cell types, e.g., stem cells, germline cells, and early embryos can elongate shortened telomeres via the enzymatic action of telomerase, which is composed of...

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PMID: 34330985
DOI: 10.1038/s41598-021-95239-5

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