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High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19.

PLoS pathogens - 1 Apr 2021

Ko Sung Hee, Bayat Mokhtari Elham, Mudvari Prakriti, Stein Sydney, Stringham Christopher D, Wagner Danielle, Ramelli Sabrina, Ramos-Benitez Marcos J, Strich Jeffrey R, Davey Richard T, Zhou Tongqing, Misasi John, Kwong Peter D, Chertow Daniel S, Sullivan Nancy J, Boritz Eli A

Abstract excerpt

Tracking evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within infected individuals will help elucidate coronavirus disease 2019 (COVID-19) pathogenesis and inform use of antiviral interventions. In this study, we developed an approach for sequencing the region encoding the SARS-CoV-2 virion surface proteins from large numbers of individual virus RNA genomes per sample. We applied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33831133
DOI: 10.1371/journal.ppat.1009431
PMCID: PMC8031304

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