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Article

Tissue tropism and functional adaptation of the SARS-CoV-2 spike protein in a fatal case of COVID-19.

Journal of virology - 25 Nov 2025

Johnson Katherine E E, Stein Sydney, Boateng Rita Afriyie, Jain Shilpi, Ramelli Sabrina C, Stantliff Trevor, Curran Shelly, Ramos-Benítez Marcos J, Platt Andrew P, Banakis Stephanie, Wang Wei, Hewitt Stephen M, Zerbe Christa, Holland Steven M, Kang Elizabeth M, Singh Manmeet, de Wit Emmie, Lauer William A, Rouchka Eric C, Smith Melissa, Suthar Mehul S, Chertow Daniel S, Ghedin Elodie

Abstract excerpt

Systemic spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to extrapulmonary tissues has been observed following acute infections. Autopsy studies further indicate tissue-specific virus diversity, including in immune-privileged sites. Questions remain on the viral dynamics leading to the tissue tropism of SARS-CoV-2, including evolutionary trajectories and functional adaptations that could...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41170974
DOI: 10.1128/jvi.00857-25
PMCID: PMC12645954

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