Article
Optimized permutation testing for information theoretic measures of multi-gene interactions.
BMC bioinformatics - 7 Apr 2021
Kunert-Graf James M, Sakhanenko Nikita A, Galas David J
Abstract excerpt
BACKGROUND: Permutation testing is often considered the "gold standard" for multi-test significance analysis, as it is an exact test requiring few assumptions about the distribution being computed. However, it can be computationally very expensive, particularly in its naive form in which the full analysis pipeline is re-run after permuting the phenotype labels. This can become intractable in multi-locus...
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