Article
Rare, Protein-Altering Variants in AS3MT and Arsenic Metabolism Efficiency: A Multi-Population Association Study.
Environmental health perspectives - 1 Apr 2021
Delgado Dayana A, Chernoff Meytal, Huang Lei, Tong Lin, Chen Lin, Jasmine Farzana, Shinkle Justin, Cole Shelley A, Haack Karin, Kent Jack, Umans Jason, Best Lyle G, Nelson Heather, Griend Donald Vander, Graziano Joseph, Kibriya Muhammad G, Navas-Acien Ana, Karagas Margaret R, Ahsan Habibul, Pierce Brandon L
Abstract excerpt
BACKGROUND: Common genetic variation in the arsenic methyltransferase (AS3MT) gene region is known to be associated with arsenic metabolism efficiency (AME), measured as the percentage of dimethylarsinic acid (DMA%) in the urine. Rare, protein-altering variants in AS3MT could have even larger effects on AME, but their contribution to AME has not been investigated. OBJECTIVES: We estimated the impact of rare,...
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