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Article

Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations.

PLoS genetics - 1 Jan 2023

Chernoff Meytal Batya, Delgado Dayana, Tong Lin, Chen Lin, Oliva Meritxell, Tamayo Lizeth I, Best Lyle G, Cole Shelley, Jasmine Farzana, Kibriya Muhammad G, Nelson Heather, Huang Lei, Haack Karin, Kent Jack, Umans Jason G, Graziano Joseph, Navas-Acien Ana, Karagas Margaret R, Ahsan Habib, Pierce Brandon L

Abstract excerpt

Inorganic arsenic is highly toxic and carcinogenic to humans. Exposed individuals vary in their ability to metabolize arsenic, and variability in arsenic metabolism efficiency (AME) is associated with risks of arsenic-related toxicities. Inherited genetic variation in the 10q24.32 region, near the arsenic methyltransferase (AS3MT) gene, is associated with urine-based measures of AME in multiple arsenic-exposed...

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Identifiers

PMID: 36668670
DOI: 10.1371/journal.pgen.1010588
PMCID: PMC9891528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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