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Article

Genetic Determinants of Reduced Arsenic Metabolism Efficiency in the 10q24.32 Region Are Associated With Reduced AS3MT Expression in Multiple Human Tissue Types.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2020

Chernoff Meytal, Tong Lin, Demanelis Kathryn, Vander Griend Donald, Ahsan Habib, Pierce Brandon L

Abstract excerpt

Approximately 140 million people worldwide are exposed to inorganic arsenic through contaminated drinking water. Chronic exposure increases risk for cancers as well as cardiovascular, respiratory, and neurologic diseases. Arsenic metabolism involves the AS3MT (arsenic methyltransferase) gene, and arsenic metabolism efficiency (AME, measured as relative concentrations of arsenic metabolites in urine) varies among...

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PMID: 32433756
DOI: 10.1093/toxsci/kfaa075
PMCID: PMC7531331

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