Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity.

doi:10.1158/1055-9965.EPI-15-0718

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Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2016

Jansen Rick J, Argos Maria, Tong Lin, Li Jiabei, Rakibuz-Zaman Muhammad, Islam Md Tariqul, Slavkovich Vesna, Ahmed Alauddin, Navas-Acien Ana, Parvez Faruque, Chen Yu, Gamble Mary V, Graziano Joseph H, Pierce Brandon L, Ahsan Habibul

Abstract excerpt

BACKGROUND: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%) varies across individuals, reflecting differences in arsenic metabolism...

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PMID: 26677206
DOI: 10.1158/1055-9965.EPI-15-0718
PMCID: PMC4767610

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