Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction.

doi:10.1093/ije/dyt182

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction.

International journal of epidemiology - 1 Dec 2013

Pierce Brandon L, Tong Lin, Argos Maria, Gao Jianjun, Farzana Jasmine, Roy Shantanu, Paul-Brutus Rachelle, Rahaman Ronald, Rakibuz-Zaman Muhammad, Parvez Faruque, Ahmed Alauddin, Quasem Iftekhar, Hore Samar K, Alam Shafiul, Islam Tariqul, Harjes Judith, Sarwar Golam, Slavkovich Vesna, Gamble Mary V, Chen Yu, Yunus Mohammad, Rahman Mahfuzar, Baron John A, Graziano Joseph H, Ahsan Habibul

Abstract excerpt

BACKGROUND: Arsenic exposure through drinking water is a serious global health issue. Observational studies suggest that individuals who metabolize arsenic efficiently are at lower risk for toxicities such as arsenical skin lesions. Using two single nucleotide polymorphisms(SNPs) in the 10q24.32 region (near AS3MT) that show independent associations with metabolism efficiency, Mendelian randomization can be used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arsenicals

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bangladesh

Share to Causality

Share to Environmental Exposure

Share to Gene-Environment Interaction

Share to Mendelian Randomization Analysis

Share to Methyltransferases

Share to Skin Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 24536095
DOI: 10.1093/ije/dyt182
PMCID: PMC3887566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction.PMID 24536095Read ↗

Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh.Semantic proximity Read ↗

Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity.Semantic proximity Read ↗

The Genetic Architecture of Arsenic Metabolism Efficiency:A SNP-Based Heritability Study of Bangladeshi Adults.Semantic proximity Read ↗

Sequencing-based fine-mapping and in silico functional characterization of the 10q24.32 arsenic metabolism efficiency locus across multiple arsenic-exposed populations.Semantic proximity Read ↗

Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh.Semantic proximity Read ↗

A missense variant in FTCD is associated with arsenic metabolism and toxicity phenotypes in BangladeshSemantic proximity Read ↗

Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study.Semantic proximity Read ↗

GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh.Semantic proximity Read ↗

Recent Advances in Arsenic Research: Significance of Differential Susceptibility and Sustainable Strategies for Mitigation.Semantic proximity Read ↗

Association of single nucleotide polymorphism with arsenic-induced skin lesions and genetic damage in exposed population of West Bengal, India.Semantic proximity Read ↗

Folate Deficiency, Hyperhomocysteinemia, Low Urinary Creatinine, and Hypomethylation of Leukocyte DNA Are Risk Factors for Arsenic-Induced Skin LesionsSemantic proximity Read ↗

Environmental arsenic exposure: From genetic susceptibility to pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.