Article
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
Molecular cell - 6 May 2021
van Vliet Thijmen, Varela-Eirin Marta, Wang Boshi, Borghesan Michela, Brandenburg Simone M, Franzin Rossana, Evangelou Konstantinos, Seelen Marc, Gorgoulis Vassilis, Demaria Marco
Abstract excerpt
Cellular senescence is a state of stable proliferative arrest triggered by damaging signals. Senescent cells persist during aging and promote age-related pathologies via the pro-inflammatory senescence-associated secretory phenotype (SASP), whose regulation depends on environmental factors. In vivo, a major environmental variable is oxygenation, which varies among and within tissues. Here, we demonstrate that...
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