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Article

Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer.

International journal of cancer - 15 May 2015

Laitinen Virpi H, Rantapero Tommi, Fischer Daniel, Vuorinen Elisa M, Tammela Teuvo L J, Wahlfors Tiina, Schleutker Johanna

Abstract excerpt

The 2q37 and 17q12-q22 loci are linked to an increased prostate cancer (PrCa) risk. No candidate gene has been localized at 2q37 and the HOXB13 variant G84E only partially explains the linkage to 17q21-q22 observed in Finland. We screened these regions by targeted DNA sequencing to search for cancer-associated variants. Altogether, four novel susceptibility alleles were identified. Two ZNF652 (17q21.3) variants,...

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Source

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Identifiers

PMID: 25335771
DOI: 10.1002/ijc.29276
PMCID: PMC4355047

Genes

EFCAB13
HDAC4
HOXB13

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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