Article
Association of polymorphisms in ZFHX1B, KCNQ5 and GJD2 with myopia progression and polygenic risk prediction in children.
The British journal of ophthalmology - 1 Dec 2021
Chen Li Jia, Li Fen Fen, Lu Shi Yao, Zhang Xiu Juan, Kam Ka Wai, Tang Shu Min, Tam Pancy Os, Yip Wilson Wk, Young Alvin L, Tham Clement C, Pang Chi Pui, Yam Jason C
Abstract excerpt
AIMS: To assess the association of single-nucleotide polymorphisms (SNPs) with myopia progression for polygenic risk prediction in children. METHODS: Six SNPs (ZC3H11B rs4373767, ZFHX1B rs13382811, KCNQ5 rs7744813, MET rs2073560, SNTB1 rs7839488 and GJD2 ) were analysed in 1043 school children, who completed 3-year follow-up, using TaqMan genotyping assays. SNP associations with progression in spherical...