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Article

Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia.

Human molecular genetics - 20 Dec 2013

Khor Chiea Chuen, Miyake Masahiro, Chen Li Jia, Shi Yi, Barathi Veluchamy A, Qiao Fan, Nakata Isao, Yamashiro Kenji, Zhou Xin, Tam Pancy O S, Cheng Ching-Yu, Tai E Shyong, Vithana Eranga N, Aung Tin, Teo Yik-Ying, Wong Tien-Yin, Moriyama Muka, Ohno-Matsui Kyoko, Mochizuki Manabu, Matsuda Fumihiko, Yong Rita Y Y, Yap Eric P H, Yang Zhenglin, Pang Chi Pui, Saw Seang-Mei, Yoshimura Nagahisa

Abstract excerpt

Severe myopia (defined as spherical equivalent < -6.0 D) is a predominant problem in Asian countries, resulting in substantial morbidity. We performed a meta-analysis of four genome-wide association studies (GWAS), all of East Asian descent totaling 1603 cases and 3427 controls. Two single nucleotide polymorphisms (SNPs) (rs13382811 from ZFHX1B [encoding for ZEB2] and rs6469937 from SNTB1) showed highly...

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Source

Identifiers

PMID: 23933737
DOI: 10.1093/hmg/ddt385

Genes

SNTB1
ZEB2

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