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Article

Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice.

International journal of molecular sciences - 15 Mar 2021

Jiao Xiaodan, Rahimi Balaei Maryam, Abu-El-Rub Ejlal, Casoni Filippo, Pezeshgi Modarres Hassan, Dhingra Sanjiv, Kong Jiming, Consalez Giacomo G, Marzban Hassan

Abstract excerpt

Lysosomal acid phosphatase 2 (Acp2) mutant mice (naked-ataxia, nax) have a severe cerebellar cortex defect with a striking reduction in the number of granule cells. Using a combination of in vivo and in vitro immunohistochemistry, Western blotting, BrdU assays, and RT-qPCR, we show downregulation of MYCN and dysregulation of the SHH signaling pathway in the nax cerebellum. MYCN protein expression is significantly...

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Acid Phosphatase
Cerebellar Ataxia
Cerebellar Cortex
Cytoplasmic Granules
Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

N-Myc Proto-Oncogene Protein

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PMID: 33804256
DOI: 10.3390/ijms22062994
PMCID: PMC7999993

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