Article
The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis.
Scientific reports - 4 Nov 2019
Lombino Franco L, Muhia Mary, Lopez-Rojas Jeffrey, Brill Monika S, Thies Edda, Ruschkies Laura, Lutz David, Richter Melanie, Hausrat Torben J, Lopes André T, McNally Francis J, Hermans-Borgmeyer Irm, Dunleavy Jessica E M, Hoffmeister-Ullerich Sabine, Frotscher Michael, Misgeld Thomas, Kreutz Michael R, de Anda Froylan Calderon, Kneussel Matthias
Abstract excerpt
Microtubule severing regulates cytoskeletal rearrangement underlying various cellular functions. Katanin, a heterodimer, consisting of catalytic (p60) and regulatory (p80) subunits severs dynamic microtubules to modulate several stages of cell division. The role of p60 katanin in the mammalian brain with respect to embryonic and adult neurogenesis is poorly understood. Here, we generated a Katna1 knockout mouse...
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