Article
Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development.
Developmental biology - 15 May 2011
McNeill Elizabeth M, Klöckner-Bormann Mariana, Roesler Elizabeth C, Talton Lynn E, Moechars Dieder, Clagett-Dame Margaret
Abstract excerpt
Development of the cerebellum involves a coordinated program of neuronal process outgrowth and migration resulting in a foliated structure that plays a key role in motor function. Neuron navigator 2 (Nav2) is a cytoskeletal-interacting protein that functions in neurite outgrowth and axonal elongation. Herein we show that hypomorphic mutant mice lacking the full-length Nav2 transcript exhibit ataxia and defects in...
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