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Potential Impacts of Interleukin-17A Promoter Polymorphisms on the EGFR Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan.

Genes - 17 Mar 2021

Lee Kai-Ling, Lai Tsung-Ching, Wang Yao-Chen, Shih Pei-Chun, Yang Yi-Chieh, Tsao Thomas Chang-Yao, Liu Tu-Chen, Wen Yu-Ching, Chang Lun-Ching, Yang Shun-Fa, Chien Ming-Hsien

Abstract excerpt

Non-small cell lung cancer (NSCLC) is a typical inflammation-associated cancer, and lung adenocarcinoma (LUAD) is the most common histopathological subtype. Epidermal growth factor receptor (EGFR) mutations are the most common driver mutations of LUAD, and they have been identified as important therapeutic targets by EGFR tyrosine kinase inhibitors. Interleukin (IL)-17A secreted by T-helper 17 lymphocytes is a...

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Identifiers

PMID: 33802737
DOI: 10.3390/genes12030427
PMCID: PMC8002550

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Source receipt: pubmed, retrieved 7 Sept 2026.

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