Article
Interleukin 17A polymorphism elevates gene expression and is associated with increased risk of nonsmall cell lung cancer.
DNA and cell biology - 1 Jan 2015
Cheng Sensen, Shao Zhulin, Liu Xiuchun, Guo Liangjun, Zhang Xia, Na Qinyun, Chen Xiaofeng, Ma Yuan, Zheng Jinsong, Song Bao, Liu Jie
Abstract excerpt
Interleukin 17 (IL-17), also known as IL-17A, is a proinflammatory cytokine and plays critical roles in tumor immunity. Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancers. The aim of this study was to investigate the correlation between IL-17A genetic polymorphisms and susceptibility to NSCLC. Two single nucleotide polymorphisms (SNPs) in IL-17A gene, rs3819024A/G and rs8193037G/A, were...
Topics
- Adenocarcinoma
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cells, Cultured
- Female
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Gene Frequency
- Genetic Association Studies