Article
Heritable methylation marks associated with breast and prostate cancer risk.
The Prostate - 1 Sept 2018
Dugué Pierre-Antoine, Dowty James G, Joo Jihoon E, Wong Ee M, Makalic Enes, Schmidt Daniel F, English Dallas R, Hopper John L, Pedersen John, Severi Gianluca, MacInnis Robert J, Milne Roger L, Giles Graham G, Southey Melissa C
Abstract excerpt
BACKGROUND: DNA methylation can mimic the effects of germline mutations in cancer predisposition genes. Recently, we identified twenty-four heritable methylation marks associated with breast cancer risk. As breast and prostate cancer share genetic risk factors, including rare, high-risk mutations (eg, in BRCA2), we hypothesized that some of these heritable methylation marks might also be associated with the risk...
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