Article

Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic SPP1 <sup>+</sup> macrophage differentiation

2024-12-17

Abstract excerpt

Eosinophils, traditionally associated with allergic responses, have emerged as critical immune modulators in colorectal cancer (CRC). Here, we reveal that eosinophils actively shape the tumor microenvironment and influence metastatic progression. Using comprehensive transcriptomics analysis of human CRC and a murine orthotopic tumor model, we identify a conserved tumor-specific eosinophil signature and activation...

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Literature Corpus work: 136a8473-69e1-5d6d-894d-518b4207068a
DOI: 10.1101/2024.12.13.628333

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