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SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance

1 Apr 2021

Abstract excerpt

The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation is associated with a poor clinical prognosis and drug resistance. The mechanism regulating JAK2 activity is complex. Although translocation of JAK2 between nucleus and cytoplasm is an important regulatory mechanism, how JAK2 translocation is regulated and what is the physiological function of this translocation remain largely...

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PMID: 33795649
DOI: 10.1038/s41419-021-03635-6

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