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Article

Emerging Roles of SKP2 in Cancer Drug Resistance

10 May 2021

Abstract excerpt

More than half of all cancer patients receive chemotherapy, however, some of them easily acquire drug resistance. Resistance to chemotherapy has become a massive obstacle to achieve high rates of pathological complete response during cancer therapy. S-phase kinase-associated protein 2 (Skp2), as an E3 ligase, was found to be highly correlated with drug resistance and poor prognosis. In this review, we summarize...

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Peptidase Inhibition and Analysis
Protein Degradation and Inhibitors
Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34068643
DOI: 10.3390/cells10051147

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