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Article

Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis.

Pediatric rheumatology online journal - 29 Feb 2016

Scheuern Andrea, Fischer Nadine, McDonald Joseph, Brunner Hermine I, Haas Johannes-Peter, Hügle Boris

Abstract excerpt

BACKGROUND: Methotrexate (MTX) intolerance is a frequent problem of long-term treatment in juvenile idiopathic arthritis (JIA). Mutations in the methylentetrahydrofolate reductase (MTHFR) gene may increase toxicity of MTX, potentially constituting an initial stimulus for this conditioned response. The objective of this study was to investigate the relationship of common MTHFR gene mutations and occurrence of MTX...

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Identifiers

PMID: 26928923
DOI: 10.1186/s12969-016-0071-y
PMCID: PMC4772529

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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