Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of fertility-preserving treatment outcomes in patients with POLE-mutated endometrioid carcinoma.

Journal of gynecologic oncology - 1 Jul 2025

Zhai Zhuoyu, Wang Yiqin, Li He, Kang Nan, Liu Yuanyuan, Wang Jianliu

Abstract excerpt

To explore the clinical outcomes of fertility-sparing treatment (FST) in patients with POLE-mutated endometrioid carcinoma (EEC). A total of 9 EEC patients who received FST and were classified to the POLE-mutated subtype in Peking University People's Hospital from April 2020 to October 2023, were retrospectively collected. Clinical and pathological data were analyzed to describe the outcomes of FST in patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Endometrioid
Share to DNA Polymerase II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to POLE gene

Share to Mutation

Share to Neoplasm Recurrence, Local

Share to Poly-ADP-Ribose Binding Proteins

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 40275683
DOI: 10.3802/jgo.2025.36.e101
PMCID: PMC12226322

Genes

POLE
FST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of fertility-preserving treatment outcomes in patients with POLE-mutated endometrioid carcinoma.PMID 40275683Read ↗

The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive ReviewSemantic proximity Read ↗

Clinicopathological characteristics and prognostic value of POLE mutations in endometrial cancer: A systematic review and meta-analysis.Semantic proximity Read ↗

The clinicopathological characteristics of POLE-mutated/ultramutated endometrial carcinoma and prognostic value of POLE status: a meta-analysis based on 49 articles incorporating 12,120 patients.Semantic proximity Read ↗

Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: An individual patient data meta-analysis.Semantic proximity Read ↗

[Clinicopathological and molecular genetic features of POLE-mutated endometrioid carcinoma].Semantic proximity Read ↗

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis.Semantic proximity Read ↗

The clinicopathology and survival characteristics of patients with POLE proofreading mutations in endometrial carcinoma: A systematic review and meta-analysis.Semantic proximity Read ↗

New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere.Semantic proximity Read ↗

POLE mutation combined with microcystic, elongated and fragmented (MELF) pattern invasion in endometrial carcinomas might be associated with poor survival in Chinese women.Semantic proximity Read ↗

Tailoring Endometrial Cancer Treatment Based on Molecular Pathology: Current Status and Possible Impacts on Systemic and Local Treatment.Semantic proximity Read ↗

Endometrial cancer with a POLE mutation progresses frequently through the type I pathway despite its high-grade endometrioid morphology: a cohort study at a single institution in Japan.Semantic proximity Read ↗

Clinicopathological and molecular characterization of high-grade endometrial carcinoma with POLE mutation: a single center study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.